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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Multimodal pulmonary clearance kinetics of carbon black nanoparticles deposited in the lungs of rats: the role of alveolar macrophages

Fig. 4

The comparison of inflammatory conditions between vehicle control (VEH), carbon black nanoparticles (CBNP)-treated rats, and CBNP-treated alveolar macrophages (AMs)-depleted rats by clodronate liposomes (CLO) treatment (CLO-CBNP). Lung inflammation was evaluated using bronchoalveolar lavage fluid analysis at day 29 (28 days after CBNP treatment). CLO was administered to rats by intratracheal instillation at 250 µg/rat on days 0 and 14 to deplete AMs. (A) Number of total cells. (B) Number of macrophages. (C) Number of granulocytes. (D) Percentage of granulocytes. (E) Level of lactate dehydrogenase (LDH). (F) Level of total protein. Note that the CLO-CBNP group showed a significant depletion of AMs (25% reduction compared with that in the CBNP group) and mild infiltration of granulocytes, approximately 13%. Data are mean ± standard error of the mean (SEM) (n = 4 for each group). *p < 0.05 compared to the VEH and #p < 0.05 compared to between groups

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Particle and Fibre Toxicology

ISSN: 1743-8977

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