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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Multimodal pulmonary clearance kinetics of carbon black nanoparticles deposited in the lungs of rats: the role of alveolar macrophages

Fig. 5

The organ burden analysis of carbon black nanoparticles (CBNPs) in normal or alveolar macrophages (AMs)-depleted rats. Clodronate liposomes (CLO) were instilled into the lungs of rats at 250 µg/rat on days 0 and 14, and CBNPs at 100 µg/rat were instilled on day 1. The retained concentrations of CBNPs in the lung and lung-associated lymph nodes (LALN) were calculated on day 29 (28 days after CBNP treatment). (A) The lung burden of CBNPs in AMs-depleted rats with CLO was approximately 31.2% lower than that in normal rats. (B) The levels of CBNPs in LALN were detectable in AMs-depleted rats (CLO), while normal rats showed no detectable levels. Data are mean ± standard error of the mean (SEM) (n = 4 for each group). *p < 0.05 compared to between groups

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Particle and Fibre Toxicology

ISSN: 1743-8977

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