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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Spatial regulation of NMN supplementation on brain lipid metabolism upon subacute and sub-chronic PM exposure in C57BL/6 mice

Fig. 7

Correlation analysis between critical lipids and neurological damage indicators in hippocampus and hypothalamus upon PM exposure. Legends (A) The correlation between the key lipids PG (38:8), PE (44:12), PI (34:1), activated microglia (iba1+), inflammatory genes (Casp1, Ccl27b, Cxcl5, Nlrc5, S100a8, S100a9, Tnfrsf11a, and Tnfrsf11b), and neurobehavioral functions indicators from open field tests (Time in central squares, Route in central squares, Overall distance) and water maze tests (Escape latency and Platform area crossings) in hippocampus. (B) The correlation between the key lipids LPC (18:3), activated microglia (iba1+), inflammatory genes (Casp1, Ccl27a, Ccl27b, Il18rap, S100a8, S100a9, Tnfrsf11a, and Tnfrsf11b), and neurobehavioral functions indicators from open field tests (Time in central squares, Route in central squares, Overall distance) and water maze tests (Escape latency and Platform area crossings) in hypothalamus. Circle size reflects the correlation coefficient magnitude, with red indicating positive correlations and blue representing negative correlations

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Particle and Fibre Toxicology

ISSN: 1743-8977

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