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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxide

Fig. 5

Global DNA methylation and hydroxymethylation changes in the liver of mice exposed to E 171. (A, B) The levels of 5-mC in the liver tissue of mice treated with E 171 for 28 (A) and 84 days (B), n = 7. (C, D) The levels of 5-hmC in the liver tissue of mice treated with E 171 for 28 (C) and 84 days (D), n = 7. (E − H) Expression levels of Dnmt1 (E), Tet2 (F), Tet3 (G), and LINE-1 ORF2 (H) in the liver of mice treated with E 171 for 84 days, n = 7. n indicates the number of mice in each group. Statistical significance is indicated as *p < 0.05 and **p < 0.01, compared with the control group

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Particle and Fibre Toxicology

ISSN: 1743-8977

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