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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: Diesel exhaust particle inhalation in conjunction with high-fat diet consumption alters the expression of pulmonary SARS-COV-2 infection pathways, which is mitigated by probiotic treatment in C57BL/6 male mice

Fig. 1

Proposed SARS-CoV-2 cellular entrance pathways. Following priming of its spike proteins by the transmembrane protease serine 2 (TMPRSS2) and/or furin protease, SARS-CoV-2 uses the angiotensin-converting enzyme (ACE2) receptor for entry into respiratory epithelial cells. The androgen receptor (AR) has been demonstrated to regulate TMPRSS2 and ACE2 expression, facilitating the priming of coronavirus S proteins and allowing entry into the host cell. Because of its ability to bind furin-cleaved substrates, neuropilin-1 (NRP1) is a proposed coreceptor for SARS-CoV-2 infection. Created withhttp://BioRender.com.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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