Fig. 1
From: Cell-nanoparticle stickiness and dose delivery in a multi-model in silico platform: DosiGUI
The in silico-in vitro pipeline leveraging DosiGUI. (A) Physicochemical characterization of ENPs (i.e., intrinsic parameters) using established methods [20, 21, 26, 27] and (B) extrinsic parameters are crucial for optimizing the reliability of delivered dose predictions and improving dose-response characterization. (C) The input dataset is fed to DosiGUI for running simulations. The same dataset can be used for both ISD3 and DG models, and the outcome can be exploited for identifying the ENP-cell stickiness. (D) DosiGUI is validated for specific ENPs by comparing predictions and experimental measurements of a fully characterized test system. (E) Once validated, DosiGUI predictions of delivered dose for a given ENP-cell combination can be extrapolated to various exposure scenarios