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Table 5 Statistical significance of the DNA damage effect and categorization for genotoxicity

From: Hazard assessment of nanomaterials: how to meet the requirements for (next generation) risk assessment

Nanoform

SBs

net Fpg

3 h

24 h

3 h

24 h

Significance

Categorization

Significance

Categorization

Significance

Categorization

Significance

Categorization

TiO2 NPs

No

Negative

No

Negative

No

Negative

No

Negative

TiO2 aggregates

No

Negative

No

Negative

No

Negative

p: 0.04#

Equivocal

TiO2 nanorods

No

Negative

p: 0.006#

Equivocal

p: 0.004#

Equivocal

No

Negative

CeO2 NPs

No

Negative

No

Negative

No

Negative

No

Negative

CeO2 aggregates

No

Negative

p: 0.048#

Equivocal

No

Negative

No

Negative

CeO2 stamps

2*; p: 0.0001#

Positive

3*; p: 0.001#

Positive

No

Negative

No

Negative

Ag 20 nm NPs

No

Negative

p: 0.009#

Equivocal

No

Negative

No

Negative

Ag 50 nm NPs

p: 0.002#

Equivocal

p: 0.001#

Equivocal

No

Negative

No

Negative

Ag nanowires

p: 0.024#

Equivocal

p: 0.020#

Equivocal

No

Negative

No

Negative

  1. Significance: *Statistically significant increase with respect to control for the number of concentrations indicated, calculated by one-way ANOVA (Dunnett’s multiple comparisons test); #Statistically significant linear trend (p < 0.05) calculated by linear regression analysis (slope significantly non-zero)