Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis

Table 1 Nano-bio interactions related to lung fibrosis

Nano-bio interactions		Quantified feature
MeONP change	Aggregation	Hydrodynamic diameter
	Surface modification	Zeta potential
	Ion release	Dissolution in SLF
	Ion release	Dissolution in PSF
Biological change	Membrane disruption	LDH release in macrophages*
	Membrane disruption	LDH release in epithelial cells*
	Lysosome dysfunction	Lysosomal pH in macrophages*
	Mitochondrial dysfunction	NADH level in macrophages*
		NADH level in epithelial cells*
		ATP level in macrophages*
		ATP level in epithelial cells*
	Redox homeostasis	ROS generation in macrophages* ROS generation in epithelial cells *
	Cytokine release	IL-1β release from macrophages*
		TNF-α release from macrophages*
		IL-6 release from macrophages*
		MCP-1 release from macrophages*
		TGF-β1 release from epithelial cells*

Note: *Features were quantified at five exposure doses: 12.5, 25, 50, 100 and 200 µg/ml

ISSN: 1743-8977