Fig. 10
From: Pro-inflammatory effects of inhaled Great Salt Lake dust particles
Effect of TRP channel inhibitors on IL6 and IL8 mRNA induction in HBEC3-KT cells. Expression of (a) IL6 and (b) IL8 mRNA by HBEC3-KT cells treated for 24 h with GSLD PM2.5 (66 µg/cm2) with and without co-treatment with the TRPV1 inhibitors LJO-328 (20 µM; red) and AMG-9810 (1 µM; red), the TRPV3 inhibitor 007 (50 µM; orange), and a combination of LJO-328 and 007 (20 + 50µM; red/orange checkered). All treatment groups were corrected for the respective controls and normalized to GSLD qPM2.5 treated cells. Data are the mean and standard deviation and were analyzed using 1-way ANOVA and a Dunnett post-test. *p < 0.05, ***p < 0.001, and ****p < 0.0001