Fig. 8
From: Pro-inflammatory effects of inhaled Great Salt Lake dust particles
Effects of metal chelators (EGTA and DFO), a non-specific calcium channel blocker (RR), and TLR4 inhibition (TAK-242) on (a) IL6 and (b) IL8 mRNA induction in HBEC3-KT cells treated for 24 h with GSLD qPM2.5 (66 µg/cm2). The concentrations of inhibitors were: EGTA + RR (10 + 50 µM; green), TAK-242 (1 µM; blue), and DFO (50µM; grey). Effects of GSLD qPM2.5 on (c) IL6 and (d) IL8 mRNA induction in HBEC3-KT cells following extraction with water and ethanol (yellow) and heating for 4 h at 500oC (brown). All treatment groups were corrected for the respective controls and normalized to GSLD qPM2.5 treated cells. Data are the mean and standard deviation and were analyzed using 1-way ANOVA and Dunnett post-test. **p < 0.01 and ****p < 0.0001