Fig. 9
From: Pro-inflammatory effects of inhaled Great Salt Lake dust particles
Activation of TRP ion channels by GSLD qPM2.5 and PM3.1−10. (a-f) Normalized (to ionomycin, 10 µM) calcium flux from HEK-293 cells transiently transfected with a control (empty) or human and mouse TRP expression plasmids following treatment with GSLD. Agonists of each channel are shown on the left side of each panel and include TRPA1 (AITC; 150µM), TRPM8 and ΔM801 (menthol; 500µM), TRPV1 (nonivamide; 20µM), and TRPV4 (GSK1016790A; 35nM). Effects of LHC9 (negative control) are on the right side of each panel. Data are the mean and standard deviation. Results were compared to the control vector for each treatment using 2-way ANOVA and a Dunnett post-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001