Fig. 4

Differentially expressed genes in human AM following overload exposure to Printex 90 particles. A-D. Representation of the 16 genes significantly differentially expressed in human AM exposed to Printex 90 overload. A. Barplot representing the logFC (overload vs. non-overload conditions) of the 16 genes in human AM. In red are the up-regulated genes and in blue the down-regulated genes. B-C. Scatterplots comparing logFC values (overload vs. non-overload) between P25 and Printex 90 in human AM (B) or between rat and human AM exposed to Printex 90 particles (C). Each dot represents one of the 16 genes. The small dots represent the logFC of each rat HTS experiment while the big dots represent the mean of logFC of the two rat experiments (C). Each regression line indicates the linear relationship between the logFC. The correlation degree between logFC was calculated by Pearson correlation coefficient R and the concordance of the values was calculated by the intraclass correlation coefficient ICC. A p-value < 0.05 indicates a significant correlation. D. Barplot representing the logFC (overload vs. non-overload conditions) of the 16 genes in rat (first and second HTS experiment) and human AM exposed to Printex 90 or P25 particles. The blue stars highlight genes, which were also significantly modulated in rat AM by overload conditions of Printex 90 or P25. Gene names are from reference genome Homo sapiens