Fig. 1

Characterization of NPs and its effect on cardiac function in mice. (A) The image of NPs. (B) Zeta potentials of NPs. (C) The hydrodynamic size of NPs. (D) Schematic diagram of the experimental procedure. (E-F) The effects of NPs at different doses on cardiac function were examined by echocardiography. (G) Effect of different doses of NPs on the expression of myocardial injury markers. (H) Effect of NPs on cardiac ultrastructure. (I-J) NPs exposure to cardiac tissue damage and collagen deposition. ^ap < 0.05, compared with the 0 mg/kg group; ^bp < 0.05, compared with the 0.6 mg/kg group; ^cp < 0.05, compared with the 3 mg/kg group, n ≥ 3