Fig. 5

Alleviating effect of Sodium propionate (ProNa) on cardiotoxicity induced by NPs. (A) Schematic diagram of ProNa intervention experiment. (B) Cell viability at different concentrations of NPs. (C) Cell viability at different concentrations of ProNa. (D) Expression of genes related to cardiac collagen deposition. (E) Gene expression of cardiac function related indicators. (F) Expression of cardiac function related indicators. (G) Gene expression of Fbp1. (H-K) immunofluorescence and western blot were used to detect the expression of FBP1 protein. ^ap < 0.05, compared with the 0 µg/mL group; ^bp < 0.05, compared with the 50 µg/mL group; ^cp < 0.05, compared with the 100 µg/mL group; ^dp < 0.05, compared with the 200 µg/mL group. ^ep < 0.05, compared with the 0 µM group; ^fp < 0.05, compared with the 0.25 µM group; ^gp < 0.05, compared with the 0.5 µM group; ^hp < 0.05, compared with the 1 µM group. **p < 0.01, *p < 0.05, ^nsp > 0.05, n ≥ 3