Fig. 6

Role of Fbp1 in cardiotoxicity induced by NPs. (A) Schematic diagram of BML-275 intervention experiment. (B) Cell viability at different concentrations of BML-275. (C) Gene expression of Fbp1. (D-E) immunofluorescence and western blot were used to detect the expression of FBP1 protein. (F) Expression of genes related to cardiac collagen deposition. (G) Gene expression of cardiac function related indicators. (H) Expression of cardiac function related indicators. ^ap < 0.05, compared with the 0 µM group; ^bp < 0.05, compared with the 5 µM group; ^cp < 0.05, compared with the 10 µM group; ^dp < 0.05, compared with the 20 µM group. **p < 0.01, *p < 0.05, ^nsp > 0.05, n ≥ 3